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Synthroid is the brand name of the drug and most doctors consider it the "gold standard" in treating hypothyroidism. 526)] than the Synthroid group [1. GoodRx suggests that the bill for a month’s supply of generic levothyroxine should run between and . ” Of course, that study is now more than ten years old. Levothyroxine monotherapy (Synthroid® or multiple generic levothyroxine [GL] formulations) is standard treatment for hypothyroidism. This is an extreme, worst case scenario. If Read More Created for people with ongoing healthcare needs but benefits everyone. On the other hand, it's more expensive than the generic levothyroxine, so most insurance companies want their clients to take the generic. Brand name Synthroid and generic levothyroxine are chemically identical hormones, l-thyroxine. 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In: American Association of Clinical Endocrinologists 27th Annual Scientific and Clinical Congress; May 16–20, 2018; Boston, MA Back in 2007 the fda tightened their standards for levothyroxine since they classify it as a drug with a narrow therapeutic index. Many will not prescribe anything else. But since the dose of what the thyroid needs is so. Levothyroxine Synthroid (levothyroxine) Prescription only Levothyroxine replaces missing thyroxine and is the preferred medicine to treat hypothyroidism. Comparative effectiveness of Synthroid(R) vs generic levothyroxine on TSH lab outcomes: a confirmatory analysis of US Medicare claims data. I will tell you the filler MCC cellulose back fires on many patients and both generic and synthroid are filled with that Re: Synthroid versus Levothyroxine (generic) "Yes, it is possible the generic brand has less of the medicine than the Synthroid. 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